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  • Title: Effects of Ca2+ and calmodulin on cyclic nucleotide metabolism in neurosecretosomes isolated from ox neurohypophyses.
    Author: Dartt DA, Torp-Pedersen C, Thorn NA.
    Journal: Brain Res; 1981 Jan 05; 204(1):121-8. PubMed ID: 6113872.
    Abstract:
    In neurosecretosomes, isolated from ox neurohypophyses, both guanylate and adenylate cyclase activity was shown to be predominantly membrane-bound. Membrane-bound adenylate cyclase was inhibited by increasing the ionized calcium concentration from 10(-7) M to 10(-5) M, but was stimulated by calmodulin in the presence of 10(-7) M and 10(-5) M ionized calcium. In contrast, neither calcium ions nor calmodulin affected the activity of membrane-bound guanylate cyclase. Soluble cyclic AMP and cyclic GMP phosphodiesterase activities increased with increasing ionized calcium concentration (10(-7) M to 10(-3) M). At 10(-7) M ionized calcium concentration, both soluble phosphodiesterase activities were stimulated by calmodulin. Both the membrane-bound phosphodiesterase activities were inhibited by a high ionized calcium concentration (10(-3) M) and not affected by calmodulin.
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