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  • Title: The importance of human intestinal diamine oxidase in the oxidation of histamine and/or putrescine.
    Author: Biegański T, Kusche J, Feussner KD, Hesterberg R, Richter H, Lorenz W.
    Journal: Arch Immunol Ther Exp (Warsz); 1980; 28(6):901-6. PubMed ID: 6114722.
    Abstract:
    Histamine, naturally methylated histamine and putrescine are good substrates for human intestinal diamine oxidase, N-Methyl-N-formylhydrazine, the constituent of the mashroom poison-gyromitrin is an inhibitor of human intestinal diamine oxidase. Burimamide inhibits more effectively mammalian intestinal diamine oxidases than pea seedling diamine oxidase, beta-aminopropionitrile is a better inhibitor of pea seedling enzyme than mammalian diamine oxidases. This inhibitory differences might be related to preference in histamine or putrescine oxidizing activity of these enzymes.
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