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  • Title: Lack of influence of histamine H1-, and H2-receptor antagonists on histamine level in rat brain.
    Author: Zandarowska E, Nowak JZ, Bielkiewicz B.
    Journal: Arch Immunol Ther Exp (Warsz); 1980; 28(6):931-4. PubMed ID: 6114723.
    Abstract:
    The intraperitoneal administration of three antihistaminic drugs of H1 type: mepyramine, diphenyhydramine (each 5 and 30 mg/kg) and danitracen (2 and 10 mg/kg) did not modify histamine level in the rat brain after 2 h. Histamine H2-receptor antagonists: cimetidine (25-250 microgram) and metiamide (100 microgram) given directly into the brain had no significant effect on histamine content after 1.5 h. L-histidine (0.5 g/kg i.p.) increased after 1.5 h histamine level in various experiments by 50-75% above control. All antihistaminic drugs did not change significantly histamine level in the brains of L-histidine-treated rats though a slight but consistent tendency to decrease the L-histidine effect in the group of H2-receptor blocking drugs was observed.
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