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  • Title: TSH binding by globulins from patients with Graves' disease.
    Author: Bíró J.
    Journal: Endocrinol Exp; 1981; 15(2):145-53. PubMed ID: 6114853.
    Abstract:
    Forty one globulin preparations from patients with Graves' disease were tested for their specific TSH binding properties and compared with their TSI activity in: 1. human thyroid membrane competition assay; 2. adenylate cyclase stimulation; 3. colloid droplet formation. The preparations tested were divided into two well distinguishable groups according to their specific TSH binding: 25 samples out of 41 contained thyrotropin binding sites similar to the globulins from normal healthy persons (A-type binding, Kd: 1.2 pmol-1 g and Bmax: 0.8 pmol g-1) and 17 samples bound TSH with lower affinity but higher capacity (B-type binding mean Kd: 15.3 pmol-1 g, mean Bmax: 2.7 pmol g-1). both A- and B-type TSH binding globulins containing samples were active in binding to human thyroid membrane, in droplet formation and adenylate cyclase stimulation. However, there was a linear correlation between the potential THS binding capacity of a B-type sample and the percentage adenylate cyclase stimulation and droplet formation, whereas the reverse correlation was found with their thyroid membrane binding activity. It was concluded that B-type TSH binding globulins may play a role in the formation and/or modification of the pathogenetic TSH action.
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