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  • Title: Interference of pentobarbitone with the contraction of vascular smooth muscle in goat middle cerebral artery.
    Author: Marín J, Rico ML, Salaices M.
    Journal: J Pharm Pharmacol; 1981 Jun; 33(6):357-61. PubMed ID: 6115006.
    Abstract:
    Pentobarbitone (10(-5) to 10(-3) M) decreased the basal tone of vascular smooth muscle of goat middle cerebral artery in a dose-dependent manner as well as relaxing established contractions induced by noradrenaline (NA) (10(-5) M), 5-hydroxytryptamine (5-HT) (10(-5) M) and KCl(120 mM). Preincubations with pentobarbitone reduced the contractions evoked by these three agents in a dose-dependent way. It also decreased Ca2+ -induced contractile responses in K+ -depolarized arteries and 5-HT-Ca2+ and NA-Ca2+ contractions dose-dependently. Contractions induced by K+ were more sensitive to the depressant actions of the drug than those produced by NA and 5-HT. The small contractions evoked by K+ and 5-HT in Ca2+ -free medium were also reduced in its presence. The antagonism Ca2+ -pentobarbitone was insurmountable. These results suggest that the drug interferes with Ca2+ entry and Ca2+ release from cells stores, and therefore with the smooth muscle contractions.
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