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  • Title: [Therapy with beta-blockers in the patients with mitral valve stenosis. Clinical and hemodynamic study].
    Author: D'Annunzio E, Mobilij A.
    Journal: Minerva Med; 1980 Oct 31; 71(42):3131-7. PubMed ID: 6115340.
    Abstract:
    Five patients with pure mitral stenosis and atrial fibrillation were studied with cardiac catheterization in the usual fashion before and after administration of 2.5 mg. of propranolol. At the end the selective left ventricular angiocardiography was performed. The following parameters were calculated: heart rate, mean pulmonary wedge pressure, left ventricular end-diastolic pressure, cardiac output, end-diastolic pressure gradient through the mitral valve. Other five patients with slight mitral stenosis and sinus rhythm were treated with propranolol (40-100 mg for day) for a period of one month. Before beginning the treatment and when it was stopped the following parameters were calculated: pulmonary wedge pressure, cardiac output (Fick), heart rate. After all ten patients were treated with propranolol for a period of 6-12 months. The haemodynamic , clinical and angiographic features are analysed and discussed. The Authors conclude asserting the utility of this drug when administered to patients with slight mitral stenosis (I or II NYHA) for its favourable effect to reduce the pulmonary wedge pressure and pulmonary congestion.
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