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  • Title: Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.
    Author: Perkins MN, Stone TW, Collins JF, Curry K.
    Journal: Neurosci Lett; 1981 May 29; 23(3):333-6. PubMed ID: 6115343.
    Abstract:
    Phosphonate analogues of carboxylic acids have been tested as antagonists of excitatory aminoacids in rat cerebral cortex. (+/-)--2-Amino-7-phosphono-heptanoic acid and the (-)-D-isomer of the pentanoate derivative were more potent and selective antagonists of N-methyl-D-aspartate (NMDA) than compounds tested previously. The results support the view that a distinct population of receptors exists which are preferentially activated by NMDA.
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