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  • Title: Pharmacokinetics and pharmacodynamics of the muscle relaxant drug Org NC-45 and each of its hydroxy metabolites in dogs.
    Author: Booij LH, Vree TB, Hurkmans F, Reekers-Ketting JJ, Crul JF.
    Journal: Anaesthesist; 1981 Jul; 30(7):329-33. PubMed ID: 6115592.
    Abstract:
    The pharmacodynamics and pharmacokinetics of Org NC-45 and each of its metabolites were studied in anaesthetized dogs. Only Org NC-45 and C3-deacetylated NC-45 produced neuromuscular blockade at the doses studied. The plasma half-lives varied from 3 to 15 min, and are about one third of that of the structurally-related compound pancuronium. Renal excretion was of the order 5-20% and the biliary excretion 7-20% 6 h after administration of each of the 4 compounds. The apparent volume of distribution after a 1 1/2 h infustion was of the same order as the extracellular fluid volume. It seems that no significant entero-hepatic recirculation occurs. Thus, long term continuous infusions of Org NC-45 may be safe.
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