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  • Title: Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase.
    Author: Macchia V, Caputo G, Mandato E, Rocino A, Adhya S, Pastan I.
    Journal: J Bacteriol; 1981 Sep; 147(3):931-4. PubMed ID: 6115852.
    Abstract:
    Guanylate cyclase, which catalyzes the synthesis of guanosine 3',5'-monophosphate, has been assayed in several strains of Escherichia coli. They include wild-type cells and mutants defective in adenylate cyclase, which is responsible for the synthesis of adenosine 3',5'-phosphate. Our results demonstrate that adenylate cyclase and guanylate cyclase are two different enzymes in E. coli and suggest that the gene that encodes adenylate cyclase also plays a regulatory role in the synthesis of guanylate cyclase.
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