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  • Title: Multicenter double-blind efficacy and safety study comparing alprazolam, diazepam and placebo in clinically anxious patients.
    Author: Cohn JB.
    Journal: J Clin Psychiatry; 1981 Sep; 42(9):347-51. PubMed ID: 6115853.
    Abstract:
    Both alprazolam and diazepam were superior to placebo for the treatment of the clinical anxiety syndrome throughout a four-week double-blind multiclinic trial in 976 outpatients. At the fourth-week evaluation of the 845 patients completing the study, the 326 patients receiving alprazolam showed significantly more improvement than the 344 patients receiving diazepam on all 4 anxiety rating scales utilized (Hamilton Anxiety Rating Scale, Physician's Global Assessment, Patient's Global Assessment, and Target Symptoms).
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