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  • Title: Migraine: a platelet disorder.
    Author: Hanington E, Jones RJ, Amess JA, Wachowicz B.
    Journal: Lancet; 1981 Oct 03; 2(8249):720-3. PubMed ID: 6116859.
    Abstract:
    The hypothesis that migraine is caused by a primary abnormality of platelet behaviour was investigated in a total of 77 migraine patients and control subjects. Platelets taken from patients with classical migraine during a headache-free period demonstrated significantly higher spontaneous platelet aggregation and platelet adhesion than platelets from controls. Platelet 5-hydroxytryptamine release within three days of a migraine attack was significantly less than that measured during a migraine-free interval. Platelets from migraine patients differ significantly in their behaviour from normal platelets, and these differences can explain the onset and recurrence of attacks.
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