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  • Title: [Effect of anti-hypertensive treatment on plasma lipids and lipoproteins (author's transl)].
    Author: Sauvanet JP, Rouffy J.
    Journal: Pathol Biol (Paris); 1981 Sep; 29(7):435-40. PubMed ID: 6117048.
    Abstract:
    The authors attempted to evaluate through a literature review, lipid and lipoprotein changes induced by anti-hypertensive drugs (especially diuretics and beta-blockers). Generally, these drugs induce a modification of the lipid and lipoprotein profile towards profile atherogenicity by a moderate increase in total cholesterol, a marked increase in triglycerides and very-low-density lipoprotein triglycerides, and a decrease in high-density lipoprotein cholesterol. In theory, these changes could decrease or cancel the reduction in cardio-vascular risk obtained through the antihypertensive treatment but current data do not allow to confirm or disprove this hypothesis. However, it is certain that adherence to a suitable life-style and good dietary habits tend to reduce the associated risk factors and compensates, at least in part, for the effects of hypotensive drugs on the lipids and lipoproteins.
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