These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Role of the vascular endothelium.
    Author: Hoak JC, Czervionke RL, Fry GL, Haycraft DL, Brotherton AA.
    Journal: Philos Trans R Soc Lond B Biol Sci; 1981 Aug 18; 294(1072):331-8. PubMed ID: 6117894.
    Abstract:
    The intact vascular endothelial surface is considered to be "non-thrombogenic", and blood platelets usually fail to adhere to ti. In this role, the endothelium serves to maintain the integrity of the vascular system by preventing the escape of blood and by preventing the build-up of solid thrombus within the vessel, which would compromise blood flow. A possible explanation for the non-thrombogenic effect of the endothelium is the presence of prostacyclin (PGI2), the potent inhibitor of platelet aggregation and adherence, which is produced and released by the endothelium in response to various stimuli. Removal of PGI2 from the endothelium by four different methods did not increase baseline platelet adherence, but did increase thrombin-induced platelet adherence from 4 to 60%. Addition of exogenous PGI2, at low concentrations reversed the enhanced thrombin-induced platelet adherence under these conditions. Although it is unlikely that prostacyclin is the sole factor regulating platelet adherence to the endothelium, it appears to play a major role in the interaction of platelets with components of the blood vessel wall.
    [Abstract] [Full Text] [Related] [New Search]