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  • Title: The effect of hydrocortisone on cholesterol metabolism of cultured human skin fibroblasts.
    Author: Henze K, Kudchodkar BJ, Chait A, Albers JJ, Bierman EL.
    Journal: Biochim Biophys Acta; 1981 Nov 23; 666(2):199-204. PubMed ID: 6118180.
    Abstract:
    Hydrocortisone in physiologic concentrations resulted in a reduction in sterol synthesis by cultured normal human skin fibroblasts. These changes were observed when [14C]acetate, [14C]octanoic acid and 3H2O were used as precursors. However, the incorporation of [3H]mevalonic acid lactone into digitonin-precipitable sterols was not affected by hydrocortisone, suggesting that hydrocortisone inhibits sterol synthesis at a site prior to the formation of mevalonic acid. In contrast, the activity of hydroxymethylglutaryl-CoA reductase was stimulated several-fold by the hormone. Thus, the inhibitory effect of hydrocortisone on the cholesterol synthetic pathway may be on hydroxymethylglutaryl-CoA synthase.
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