These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Synthesis and biological activity of substituted 2-(4-imidazolyl)ethylamines].
    Author: Plazzi PV, Bordi F, Vitto M, Impicciatore M.
    Journal: Farmaco Sci; 1981 Nov; 36(11):931-31. PubMed ID: 6118297.
    Abstract:
    The synthesis of 2-(4-imidazolyl)ethylamines with hydrocarbon substituents on the heterocyclic ring or on the side-chain, from 2-acylbutyrrolactones (V) or from similar ester-type open structures (VII) is described in this paper. In particular, the results already obtained, show that the scheme given for the preparation of 2-(5-methyl-4-imidazolyl)ethylamines can be rendered general, by suitable variations correlated more with side-chain branching, than with the nature of the heterocyclic ring substituents. Synthetized imidazolyethylamines have been preliminarily tested for their properties towards H2 receptors and, secondly, towards H1 receptors.
    [Abstract] [Full Text] [Related] [New Search]