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  • Title: Is glucagon a choleretic hormone at physiologic blood levels?
    Author: Garberoglio CA, Bickerstaff KI, Baker AL, Moossa AR.
    Journal: Am J Surg; 1982 Jan; 143(1):61-6. PubMed ID: 6119034.
    Abstract:
    The mechanism of action and possible physiologic implications of glucagon-induced choleresis were investigated in two groups of dogs. Group I demonstrated, in chronic animal models, that glucagon-induced choleresis was not associated with increased bile acid output and was not blocked by somatostatin or Piptal, suggesting a direct stimulatory effect on bile acid-independent canalicular flow. In acute animal models (group II), glucagon infusion at rates which produced postprandial levels in the portal vein induced significant choleresis, implying that glucagon may have a physiologic role in the regulation of bile secretion. No consistent relation between bile secretion and portal venous blood flow could be demonstrated.
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