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  • Title: [Analysis of frequency facilitation in neuromuscular synapses of the sartorius muscle in frogs].
    Author: Zefirov AL.
    Journal: Biull Eksp Biol Med; 1981 Oct; 91(10):389-92. PubMed ID: 6119124.
    Abstract:
    Changes in the quantum content of end plate potentials (EPPs) were studied in experiments on the frog sartorius muscle in the course of a gradual increase in stimulation frequency (frequency facilitation). It was shown that the frequency facilitation coefficient does not depend on the initial quantum content of EPPs but is in good agreement with the initial frequency of miniature EPPs and in bad agreement with their amplitude. The frequency facilitation is accompanied by the growth of the statistical binomial parameters P and n. The increase in P parameters is consequent of interference in P changes during the second component of facilitation after the single impulse. The growth of n is accounted for by the summation of the n increase during the first component of facilitation the time course of which is prolonged on repetitive stimulation.
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