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  • Title: Evaluation of cefoxitin prophylaxis for cesarean section.
    Author: Dillon WP, Seigel MS, Lele AS, O'Leary JA.
    Journal: Int J Gynaecol Obstet; 1981 Apr; 19(2):133-9. PubMed ID: 6119244.
    Abstract:
    Prophylactic cefoxitin was evaluated in 101 patients undergoing cesarean section. A three-dose regimen of either cefoxitin or placebo was administered randomly in a double-blind manner, 46 patients receiving cefoxitin and 55 placebo, with the first dose given after the cord was clamped. In the placebo group, 29% of the patients developed pelvic or wound infection, compared to 4% in the cefoxitin group (P less than 0.003). No patient required re-operation, re-admission, or had a life threatening infection. Ten risk factors for infection were analyzed to help ascertain which patients would benefit from prophylaxis. Cefoxitin, with a broad spectrum of aerobic and anaerobic coverage, was found to be an effective and safe prophylactic agent when given to all patients undergoing cesarean section.
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