These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Decline in respiratory control ratio of rat liver mitochondria in old age.
    Author: Horton AA, Spencer JA.
    Journal: Mech Ageing Dev; 1981 Nov; 17(3):253-9. PubMed ID: 6119403.
    Abstract:
    Rat liver mitochondria isolated from old animals (27-33 months) showed a clear decline in the state 3 rate of respiration (presence of ADP) compared with mitochondria from mature animals (3-12 months) when using either succinate or NAD+-linked substrates. The state 4 rate of respiration (absence of ADP), which is a sensitive indicator of damage to the inner mitochondrial membrane, remained unchanged. Consequently the respiratory control ratio (state 3/state 4) declined. A loss of reserve capacity to maintain the ADP:O ratio was also observed. These observations indicate a decline in energy production in old animals.
    [Abstract] [Full Text] [Related] [New Search]