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  • Title: The new histamine H2-receptor antagonist ranitidine. Duration of action.
    Author: Dammann HG, Simon B.
    Journal: Scand J Gastroenterol Suppl; 1981 Jun; 69():39-43. PubMed ID: 6119781.
    Abstract:
    The antisecretory effects of a new histamine H2-receptor antagonist ranitidine hydrochloride 150 mg, have been tested on basal and pentagastrin-stimulated acid secretion in healthy volunteers 5 and 10 h after oral administration. In addition, the 24 h intragastric pH-profiles have been measured in patients undergoing parenteral nutrition after three oral doses of ranitidine 150 mg per day. A significant inhibition of basal acid output has been observed up to 10 h after the drug. The intragastric pH remained above 5 for at least 24 h. Ranitidine has proven to be a more potent and longer acting antisecretory compound than cimetidine.
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