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  • Title: Cytoplasmic immunoglobulins in giant lymph node hyperplasia (Castleman's tumour).
    Author: Dura WT, Mioduszewska O, Porwit-Ksiazek A.
    Journal: Virchows Arch B Cell Pathol Incl Mol Pathol; 1981; 38(2):239-46. PubMed ID: 6119848.
    Abstract:
    The immunohistologic features were studied in 6 cases of giant lymph node hyperplasia (GLNH) and the cytoplasmic immunoglobulin (CIg) characteristics were compared with those of follicular lymphoma and non-specific follicular lymph node hyperplasia. By use of the peroxidase - antiperoxidase (PAP) technique it was shown that GLNH comprised a mosaic, polyclonal population of CIG-producing cells, the CIg pattern being comparable with that observed in follicular lymphadenitis. In contrast, follicular lymphomas disclosed a definite monoclonal pattern, the cytoplasmic Ig containing only one light chain of kappa type. This led to the conclusion that GLNH is not a neoplastic change, but has the characteristics of a reactive process within the B-cell compartment.
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