These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Clinico-chemical diagnosis of the cholestasis syndrome].
    Author: Ohlen J, Drescher M, Selmair H.
    Journal: Fortschr Med; 1982 Jan 14; 100(1-2):10-15. PubMed ID: 6120134.
    Abstract:
    1. Cholestatic reactions of various etiology are biochemically established by determination of alkaline phosphatase, gamma-glutamyltranspeptidase (and leucinaminopeptidase) activities and of bile acid concentrations in serum. 2. The pathomechanisms of elevated serum activities of AP, gamma-GT and LAP in cholestatic diseases are - an induction of these canalicular membrane bound enzymes, probably due to an intracellular increase of bile acids, - a partial solubilization of canalicular membrane structure (detergent effect of bile acids), - a histochemically and morphologically demonstrable change of liver cell polarity. 3. A discrimination of intra- or extrahepatic cholestasis only by means of biochemical parameters is impossible. 4. Additional serological and immunological parameters often demonstrate the etiology of cholestatic diseases; a short review is given.
    [Abstract] [Full Text] [Related] [New Search]