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  • Title: Hypokinesia in mice and catalepsy in rats elicited by morphine associated with antidopaminergic agents, including atypical neuroleptics.
    Author: Barghon R, Protais P, Colboc O, Costentin J.
    Journal: Neurosci Lett; 1981 Nov 18; 27(1):69-73. PubMed ID: 6120489.
    Abstract:
    The interaction of morphine with agents displaying antidopaminergic properties (low dose of apomorphine, alpha-methyl-p-tyrosine, the "classical" neuroleptic haloperidol as well as the "atypical" neuroleptics sulpiride, thioridazine, clozapine and mezilamine) has been studied both on locomotor activity in mice and catalepsy in rats. At the tested doses most of the drugs induced neither catalepsy nor akinesia, but when they were associated with morphine these effects were plainly observed. It is suggested that a hyperactivity of dopaminergic systems mask the cataleptic effect of morphine.
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