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  • Title: Induction of action potentials in frog slow muscle fibres paralysed by alpha -bungarotoxin.
    Author: Miledi R, Uchitel OD.
    Journal: Proc R Soc Lond B Biol Sci; 1981 Oct 14; 213(1191):243-8. PubMed ID: 6120517.
    Abstract:
    Slow muscle fibres in the frog are normally incapable of generating action potentials. However, several days after an intramuscular injection of alpha - bungarotoxin, they acquire the ability to generate action potentials. It appears that alpha -bungarotoxin induces the action potential mechanism in slow fibres because it blocks acetylcholine receptors, and thus interferes with the action of non-quantal acetylcholine leaking from nerve terminals, or because the toxin has some other, as yet undefined, action on nerve or muscle.
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