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  • Title: Persistence of tick-borne encephalitis virus in monkeys. II. Effectiveness of methods used for virus detection.
    Author: Pogodina VV, Malenko GV, Fokina GI, Levina LS, Koreshkova GV, Rzhakhova OE, Bochkova NG, Mamonenko LL.
    Journal: Acta Virol; 1981 Nov; 25(6):344-51. PubMed ID: 6120635.
    Abstract:
    Fifty monkeys (Macaca rhesus) inoculated with tick-borne encephalitis (TBE)virus intracerebrally or subcutaneously were examined. The efficiencies of different virus detection methods at 90 to 783 days after inoculation were: explantation of organs - 41.2%; co-cultivation of trypsinized organ cells and indicator cells in the presence of 5-bromo-2-iododeoxyuridine with detection of the virus-specific antigen by immunofluorescence - 43.7%, detection of infectious virus and complement-fixing antigen - 13.6%; immunofluorescence examination of organ impression smears - 29.3%; and examination of organ homogenates with detection of virus pathogenic for mice - 1.7%. the latter method was the least sensitive for the detection of persisting TBE virus, in spite of that in the first 3 weeks of infection its efficacy was 88.1% in examinations of clinically ill monkeys and 23.8% in the inapparent form of the infection.
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