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  • Title: Occurrence of amantadine- and rimantadine-resistant influenza A virus strains during the 1980 epidemic.
    Author: Heider H, Adamczyk B, Presber HW, Schroeder C, Feldblum R, Indulen MK.
    Journal: Acta Virol; 1981 Nov; 25(6):395-400. PubMed ID: 6120642.
    Abstract:
    The sensitivities to amantadine and rimantadine of influenza A virus epidemic strains were assayed by the haem-adsorption reduction test in mouse Ehrlich ascites cells in comparison with prototype strains and a rimantadine-resistant mutant. Besides a majority of sensitive strains, two relatively resistant epidemic strains were identified. The possible origin of resistant strains and their importance for medical practice are discussed.
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