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  • Title: Speed of onset of pharmacodynamic activity of propranolol, practolol, oxprenolol and metoprolol after intravenous infection in man.
    Author: Lochan R, Silke B, Taylor SH.
    Journal: Br J Clin Pharmacol; 1981 Nov; 12(5):721-4. PubMed ID: 6120711.
    Abstract:
    1 The speed of onset of the pharmacodynamic activity of intravenous propranolol, practolol, oxprenolol and metoprolol was determined, using attenuation of isoprenaline-induced tachycardia as the end-point, in 16 patients with clinically coronary heart disease. 2 Antagonism was evident within 15 s of injection into the central circulation of all four drugs. The time to maximum attenuation of isoprenaline tachycardia was significantly more rapid with propranolol and oxprenolol than with practolol and metoprolol.
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