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  • Title: Effects of cimetidine and ranitidine on hepatic drug metabolism.
    Author: Breen KJ, Bury R, Desmond PV, Mashford ML, Morphett B, Westwood B, Shaw RG.
    Journal: Clin Pharmacol Ther; 1982 Mar; 31(3):297-300. PubMed ID: 6120774.
    Abstract:
    Cimetidine has been shown to impair elimination of a number of drugs metabolized by the hepatic mixed-function oxidase enzymes. It is uncertain whether this is related to its histamine H2-receptor antagonism or to its intrinsic structure. Ranitidine is a more potent H2-receptor antagonist and has a completely different structure. Cimetidine (1 gm/day for 7 days) induced a 23% and 35% fall in mean systemic clearance of antipyrine and theophylline, whereas ranitidine (300 mg/day 7 days) had no significant effect on the clearance of either drug. Our data suggest that the inhibition of drug metabolism by cimetidine is not related to histamine H2-receptor antagonism.
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