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  • Title: Metabolism of carbamazepine and its epoxide metabolite in human and rat liver in vitro.
    Author: Tybring G, von Bahr C, Bertilsson L, Collste H, Glaumann H, Solbrand M.
    Journal: Drug Metab Dispos; 1981; 9(6):561-4. PubMed ID: 6120817.
    Abstract:
    The epoxidation of carbamazepine (CBZ) and the hydration of the primary epoxide metabolite was studied in microsomes isolated from ten human livers. To study the epoxide hydrolase activity a high-performance liquid-chromatographic method was developed for the analysis of dihydro-CBZ-trans-diol. There was a pronounced variation between the specimens in the activity of both enzymes. There appeared to be a positive correlation between the activity of the two enzymes. In rats pretreated with either CBZ or phenobarbital for 4 days, the microsomal epoxidation of CBZ was induced. The epoxide hydrolase activity was also increased, although less so than in epoxidation.
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