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  • Title: Des-tyr-gamma-endorphin (DT gamma E) and pineal levels of melatonin and arginine vasopressin (AVP).
    Author: King MG, Geffard MR, Chavreau J, Gaffori O, Le Moal M, Muyard JP.
    Journal: Eur J Pharmacol; 1981 Dec 03; 76(2-3):271-4. PubMed ID: 6120844.
    Abstract:
    In this experiment we investigated in rats the effects of chronic injections (13 X 1.0 microgram and 13 X 2 micrograms i.m.) and one acute injection (0.3 microgram s.c.) of des-Tyr-gamma-endorphin (DT gamma E) on the pineal content of melatonin and arginine vasopressin (AVP). Compared with control levels all three regimens of DT gamma E significantly elevated pineal melatonin. The greatest increase was obtained with the 0.3 microgram acute dose while the smallest increase was obtained with the 2 micrograms chronic dose. In contrast to the effect on melatonin, pooled levels of pineal AVP were lower in DT gamma E treated rats than in control rats. The greatest reduction was obtained with the 2 microgram chronic dose and the smallest reduction was obtained with the 1 microgram chronic dose.
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