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  • Title: The antiarrhythmic effect of prostaglandin E2 on catecholamine-induced arrhythmias.
    Author: Mest HJ, Winkler J, Förster W.
    Journal: Acta Biol Med Ger; 1977; 36(7-8):1193-6. PubMed ID: 612098.
    Abstract:
    The antiarrhythmic effect of PGE2 as compared with the adrenergic beta-receptor blocking substance propranolol and the unspecific antiarrhythmic agent ajmaline was examanined on catecholamine-induced arrhythmias of the guinea-pig after preliminary sensibilisation by means of chloroform. Prophylactic administration of the tested substances resulted in a decrease in severity of arrhythmia by 91% after propranolol, by 37% after PGE2 and by 34% after ajmaline. Onset and duration of the arrhythmia were affected only to a negligible degree. The possible mode of action is still under discussion.
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