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  • Title: Aspartate: possible neurotransmitter in cerebellar climbing fibers.
    Author: Wiklund L, Toggenburger G, Cuénod M.
    Journal: Science; 1982 Apr 02; 216(4541):78-80. PubMed ID: 6121375.
    Abstract:
    Autoradiography demonstrated prominent retrograde labeling of olivocerebellar climbing fiber neurons after injection of tritiated D-aspartate into the rat cerebellar cortex or deep nuclei. Mossy fiber systems originating in the brainstem and spinal cord remained unlabeled. Potassium ion-induced depolarization of cerebellar slices resulted in calcium ion-dependent release of endogenous L-aspartate, L-glutamate, gamma-aminobutyric acid, and glycine. A 26 percent decrease in aspartate release was observed after 3-acetylpyridine-induced destruction of the inferior olive, supporting the hypothesis that aspartate is a neurotransmitter in climbing fibers.
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