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  • Title: A new beta 2-adrenoceptor agonist with alpha 1-adrenoceptor blocking properties.
    Author: Olsson OA, Ahlquist B, Gustafsson B.
    Journal: Acta Pharmacol Toxicol (Copenh); 1981 Apr; 48(4):340-8. PubMed ID: 6121453.
    Abstract:
    The phenylethanolamine D2343 exhibits a dualistic adrenoceptormediated effect, i.e, a beta-agonistic effect combined with an alpha-antagonistic one. Tracheal smooth muscles and heart preparations were used to gauge the agonistic effect of adrenergic beta-receptors. Rabbit aorta and rat vas deferens were used to determine the alpha-adrenoceptor blocking activity. The beta-adrenoceptor activity of D2343 was classified as beta 2-type with about the same efficacy as the beta 2-selective terbutaline on tracheal muscle. The effect on isolated heart preparations was greater than that produced by terbutaline. The alpha-receptor blocking capacity was directed against the alpha 1-receptor type and was of nearly the same potency as for phentolamine.
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