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  • Title: Ketotifen: a new drug for prophylaxis of asthma in children.
    Author: Simons FE, Luciuk GH, Becker AB, Gillespie CA.
    Journal: Ann Allergy; 1982 Mar; 48(3):145-50. PubMed ID: 6121527.
    Abstract:
    Ketotifen, an orally active, prophylactic anti-asthmatic drug, was compared with placebo in a double-blind, three-month parallel-group trial in 20 children. Children receiving ketotifen were more likely to reduce concomitant medications and had significant improvement over time in asthma scores and mean flows at 75%, 50%, and 25% of vital capacity. They also had a significantly increased incidence of dry mouth and significant weight gain compared to those receiving placebo. In some children with asthma, ketotifen may be a useful alternative to existing drugs.
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