These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Characterization of ouabain receptor in neuronal tissue: evidence for endogenous ouabain-like compound.
    Author: Lichtstein D, Samuelov S.
    Journal: Isr J Med Sci; 1982 Jan; 18(1):45-50. PubMed ID: 6121774.
    Abstract:
    This study shows that [3H]ouabain binds specifically to a single, saturable binding site located on rat brain membranes with an affinity constant of 6.21 X 10(-8) M. As expected from studies on the mechanics of the Na+,K+-ATPase, sodium increased while potassium and lithium decreased ouabain binding. The occupation of other neurotransmitter receptors did not affect [3H]ouabain binding. Based on its ability to compete with [3H]ouabain binding and to inhibit Na+,K+-ATPase, it is suggested that rat brain extract contains an endogenous ouabain-like compound. The results are discussed with respect to the possibility that the ouabain receptor is a physiological regulatory site of the Na+,K+-ATPase activity.
    [Abstract] [Full Text] [Related] [New Search]