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  • Title: Susceptibility of Plasmodium falciparum to pyrimethamine and sulfadoxine/pyrimethamine in Kisumu, Kenya.
    Author: Nguyen-Dinh P, Spencer HC, Chemangey-Masaba S, Churchill FC.
    Journal: Lancet; 1982 Apr 10; 1(8276):823-5. PubMed ID: 6122056.
    Abstract:
    Field studies were conducted in Kisumu, Kenya, to assess the susceptibility of local strains of Plasmodium falciparum to pyrimethamine alone (by a standard 7-day in-vivo test and a 48 h in-vitro field test) and to sulfadoxine-pyrimethamine (by a 7-day in-vivo test). Both in-vivo (10/11) and in-vitro (19/21) tests demonstrated that pyrimethamine resistance was very common. Parasite susceptibility to sulfadoxine-pyrimethamine was uniformly greater when 24 isolates were tested in vivo, thus indicating that this drug combination remains valuable despite the high frequency of resistance to pyrimethamine alone.
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