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  • Title: Biotin enhances guanylate cyclase activity.
    Author: Vesely DL.
    Journal: Science; 1982 Jun 18; 216(4552):1329-30. PubMed ID: 6123152.
    Abstract:
    Biotin and its analog, (+)-biotin-p-nitrophenyl ester enhanced guanylate cyclase activity two- to threefold in rat liver, kidney, colon, cerebellum, and heart. Dose-response relationships revealed that at concentrations as low as 1 micromolar, both biotin and its analog caused maximal augmentation of guanylate cyclase activity. These data suggest a role for the activation of guanylate cyclase in the mechanism of action of this vitamin.
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