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  • Title: The low affinity component of [3H]spiperone binding reflects association to a non-dopaminergic, neuroleptic site.
    Author: Beart PM, Krstich M, McDonald D, Gundlach AL.
    Journal: Neurosci Lett; 1982 Apr 16; 29(2):147-51. PubMed ID: 6123968.
    Abstract:
    The pharmacological properties of a low affinity site labelled by [3H]spiperone in membranes prepared from the rat nucleus accumbens were examined by investigating the ability of dopaminergic agonists, antagonists and various other drugs to displace the binding of 2 nM [3H]spiperone. Neuroleptic drugs were the most potent displacers of binding, and dopaminergic agonists, except for bromocryptine and lergotrile, had inhibition constants greater than 1 microM. The majority of drugs studied exhibited a high selectivity for the high affinity site labelled by [3H]spiperone and low affinity sites probably represent a non-specific, non-dopaminergic site for neuroleptic drugs.
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