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  • Title: [Therapeutic effect of trandat, an alpha- and beta-adrenergic receptor blockader, and its effect on central, regional and intracardiac hemodynamics].
    Author: Erina EV, Charyev KhE, Beliakova EV, Tverskaia LV, Kukharchuk VV.
    Journal: Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR; 1982; 5(1):68-74. PubMed ID: 6124260.
    Abstract:
    A study of the effect of labetalol (trandat) was carried out in 75 arterial hypertensive patients. The central, regional, and intracardial hemodynamics were studied in 40 of them by echocardiography and rheography. A 25% decrease in BP and subjective improvement were observed on the 1-2 week of treatment. Total peripheral vascular resistance decreased by 22.4%, heart rate - 7%, intramyocardial tension - 21%, left ventricular wall thickness and myocardial mass - 2.5%; brain and crural vascular tone also decreased. Cardiac index, ejection fraction, and left ventricular circumferential shortening velocity were not changed. In fourteen patients there was observed a significant decrease in the plasma renin activity. A number of advantages of trandat effect was found as compared to the effect of propranolol: blood pressure decreased at the account of the total peripheral vascular resistance diminution without suppression of myocardial contractility; the regional blood circulation was improved.
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