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  • Title: Effect of enzyme induction on nephrotoxicity of halothane-related compounds.
    Author: Hitt BA, Mazze RI.
    Journal: Environ Health Perspect; 1977 Dec; 21():179-83. PubMed ID: 612443.
    Abstract:
    Nephrotoxicity following administration of methoxyflurane has been shown to be directly related to anesthetic metabolism to inorganic fluoride. Enzyme induction should increase metabolic rate and the amount of inorganic fluoride that is released. In vivo studies in Fischer 344 rats show that enzyme induction with phenobarbital or phenytoin increases defluorination following methoxyflurane anesthesia but not after enflurane or isoflurane. In vitro, methoxyflurane defluorinase activity was increased far more than that of any of the other anesthetics. These data suggest that treatment with enzyme inducing drugs increases the risk of nephrotoxocity only if methoxyflurane is the anesthetic agent.
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