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  • Title: [Measurement of serum activity in short and long-term application of various hormonal contraceptives].
    Author: Klinger G, Gaida P, Fleischhauer HJ, Carol W.
    Journal: Z Gesamte Inn Med; 1981 Sep 01; 36(17):611-20. PubMed ID: 6125064.
    Abstract:
    The influence of several oral contraceptives on various serum enzymes was tested during a short-term and a prolonged (24 therapeutic cycles) application period. A total of 8,790 examinations was performed in 211 females, each patient being examined up to 8 times during the cycles 0, 1, 3, 6, 12, 18, 24 and the first cycle following termination of oral contraception. Since sufficiently sensitive steroid-dependent makers are lacking, it cannot be dispensed with determining the serum enzymes gamma-GT, GPT, GOT, and LAP altogether, in order to detect early damage of the liver. The influence of several oral contraceptives (OCs) on various serum enzymes was tested during a short-term and a prolonged (24 therapeutic cycles) application period. A total of 8790 examinations were performed in 211 females, each patient being examined up to 8 times during the cycles 0, 1, 3, 6, 12, 18, 24, and the 1st cycle following termination of OCs. Since sufficiently sensitive steroid-dependent markers are lacking, it cannot be dispensed with determining the serum enzymes gamma-GT, GPT, GOT, and LAP altogether, in order to detect early damage to the liver. (author's modified)
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