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  • Title: Cyclic nucleotide phosphodiesterase activity in patients with obstructive airways disease.
    Author: Polson JB, Krzanowski JJ, Goldman AL, Szentivanyi A.
    Journal: Allergol Immunopathol (Madr); 1982; 10(2):101-4. PubMed ID: 6125092.
    Abstract:
    Cyclic nucleotide phosphodiesterase activity was examined in the pulmonary tissues of patients with no obstructive airways disease, obstructive airways disease responsive to isoproterenol (responders) and obstructive airways disease non-responsive to isoproterenol (non-responders). The phosphodiesterase catalyzed hydrolysis of 0.45 microM levels of adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) was essentially the same in responders as in patients without disease, but was reduced in the non-responders. The results suggest that neither the postulated beta adrenergic receptor-cAMP system defect nor the depressed levels of cAMP reported in patients with bronchodilator-responsive obstruction is caused by an alteration of phosphodiesterase activity.
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