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  • Title: Influence of beta-adrenergic antagonism on the response of bovine neonatal lungs to intravenous histamine.
    Author: Kotlikoff MI, Slocombe RF, Robinson NE.
    Journal: Am J Vet Res; 1982 Jun; 43(6):984-8. PubMed ID: 6125115.
    Abstract:
    The effects of IV histamine infusion and beta-adrenergic blockade on pulmonary function were studied in neonatal Holstein calves, beta-Adrenergic blockade with IV propranolol increased total pulmonary resistance, but was without effect on lung compliance, lung volumes, and gas exchange. beta-Adrenergic blockade enhanced the histamine-induced increase in total pulmonary resistance and the decrease in dynamic and quasistatic compliance, lung volumes, and arterial oxygen tension. These data indicate that beta-adrenergic receptors may be present in the large and small airways of cattle and they modulate the effects of bronchoconstrictor agents as in other species.
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