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  • Title: Stable isotope analysis by fast-atom bombardment labeling of UDP-glucuronic acid.
    Author: Fenselau C, Feng PC, Chen T, Johnson LP.
    Journal: Drug Metab Dispos; 1982; 10(4):316-8. PubMed ID: 6126327.
    Abstract:
    Fast-atom bombardment mass spectrometry is found to provide a method for analysis of isotopes in the enzyme cofactor uridine-5'-diphosphoglucuronic acid, heretofore unsusceptible to mass-spectral characterization. This technique was used to determine optimal conditions for the introduction of 18O by acid-catalyzed exchange in H218O and to evaluate the loss of the isotope when labeled cofactor is used in enzymatic incubations. Fast-atom bombardment mass spectrometry provided a quantitative assessment of various isotopic species and also permitted the location of the isotopes in the molecule to be determined.
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