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  • Title: alpha 1-adrenergic receptor involvement in the LH surge in ovariectomized estrogen-primed rats.
    Author: Drouva SV, Laplante E, Kordon C.
    Journal: Eur J Pharmacol; 1982 Jul 09; 81(2):341-4. PubMed ID: 6126373.
    Abstract:
    The circadian pattern of LH release observed in ovariectomized estrogen-implanted rats was inhibited by blockade of alpha-adrenergic receptors by phenoxybenzamine; in contrast, blockade of beta-receptors by propranolol was ineffective. Prasozin, an alpha 1-antagonist, was as effective as phenoxybenzamine, whereas yohimbine, an alpha 2-antagonist, was effective only at high doses. Neither phenoxybenzamine nor prazosin were able to modify the LHRH-induced release of LH from superfused pituitaries. These results suggest an involvement of hypothalamic alpha 1-receptors in the control of circadian LH release.
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