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  • Title: Effect of calmodulin inhibitor, Stelazine, on the endocytosis of vitellogenin and transglutaminase activity in Xenopus laevis oöcytes.
    Author: Tucciarone LM, Lanclos KD.
    Journal: Mol Cell Biochem; 1982 Jun 25; 45(3):159-61. PubMed ID: 6126807.
    Abstract:
    The specific endocytosis of vitellogenin was measured in the presence of various concentrations of Stelazine, a specific inhibitor of the calcium regulating protein, calmodulin. Stelazine (200 microM) was found to inhibit the endocytosis of vitellogenin by 63% as determined by decreased uptake of vitellogenin into transitional yolk bodies and yolk platelets. The enzymatic activity of transglutaminase, a calcium-requiring enzyme implicated in receptor-mediated endocytosis, was not affected by these concentrations of Stelazine.
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