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  • Title: [Problems and future perspectives in the treatment of Parkinson's disease].
    Author: Hens L, Hellemans J.
    Journal: Tijdschr Gerontol Geriatr; 1982 Aug; 13(4):147-54. PubMed ID: 6127822.
    Abstract:
    The most prominent neuropathological lesions in Parkinson's disease have been found in the substantia nigra. The neurochemical alterations are numerous; the most prominent one is the imbalance between acetylcholine and dopamine, the latter transmitter being deficient. Up to now the striato-nigral dopaminergic receptor is the best investigated and the most useful target for an effective therapy. However, a more specific modulation, stimulation or blockade of these receptors, could strongly reduce the occurrence of the side-effects and the drug resistance that are to be seen after a dopamine substitution started too early or too vigorously.
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