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  • Title: Forskolin stimulates renin release from the isolated perfused rat kidney.
    Author: Schwertschlag U, Hackenthal E.
    Journal: Eur J Pharmacol; 1982 Oct 15; 84(1-2):111-3. PubMed ID: 6128235.
    Abstract:
    Forskolin, a novel receptor-independent adenylate cyclase activator, stimulated renin release from the isolated perfused rat kidney twofold at 10(-7) M and threefold at 10(-6) M. This stimulation was blocked by angiotensin II but not by the beta-adrenoceptor antagonist atenolol. These findings strengthen the concept that an intracellular increase of 3',5'-cyclic AMP by adenylate cyclase activation can induce stimulation of renin release.
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