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  • Title: Are the prejunctional histamine receptors on sympathetic nerve terminals in guinea-pig isolated atria activated during anaphylaxis in vitro?
    Author: Wong-Dusting H, Story DF, Rand MJ.
    Journal: J Pharm Pharmacol; 1982 Oct; 34(10):653-7. PubMed ID: 6128388.
    Abstract:
    In isolated atria from sensitized guinea-pigs, antigenic challenge with ovalbumin induces an anaphylactic reaction in which there is an increased rate and force of contraction. At the same time, stimulation-induced release of [3H] noradrenaline is inhibited by 40%. Cimetidine decreased the tachycardia occurring during anaphylaxis but no effect on the inhibition of stimulation-induced transmitter release. It is known that antigenic challenge of sensitized guinea-pig atria release histamine from mast cells; this histamine acts postjunctionally to increase heart rate. However, the inhibition of noradrenergic transmitter release is not due to the stimulation of prejunctional inhibitory histamine receptors.
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