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  • Title: A controlled clinical trial of alprazolam for the treatment of anxiety.
    Author: Rickels K, Csanalosi I, Greisman P, Cohen D, Werblowsky J, Ross HA, Harris H.
    Journal: Am J Psychiatry; 1983 Jan; 140(1):82-5. PubMed ID: 6128927.
    Abstract:
    The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of alprazolam, a triazolobenzodiazepine; diazepam, a 1,4-benzodiazepine; and placebo in 151 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam.
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